Sodium Hydroxide → 2-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

HRID 1413323Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413323
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:4][CH:3]=1.[Br:16][CH:17]([CH2:21][Br:22])[C:18](Cl)=[O:19].[OH-].[Na+]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:18](=[O:19])[CH:17]([Br:16])[CH2:21][Br:22])[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH3:15])[O:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 867902,3-Dibromopropanoyl chlorideHCID 20291464p-Chlorophenyl-5-methoxymethyl oxazolidine

Produkt 1

HCID 202914622-p-Chlorophenyl-2(2,3-dibromopropionyl)5-methoxymethyl oxazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To 20.8 milliliters of 25 percent w/v, p-chlorophenyl-5-methoxymethyl oxazolidine solution in 50 milliliters of benzene was added 5 grams of 2,3-dibromopropionyl chloride. To this solution was added 1.6 grams of 50% sodium hydroxide. After washing with water, drying and removal of the benzene in vacuo, there was obtained 4.8 grams of the title compound, nD30 1.5478. Analytical data supports the structure.

Aufarbeitung

  1. washAfter washing with water
  2. customdrying
  3. customremoval of the benzene in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3fb7dcb038144c808c643805cafe75c7
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04249931

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