Sodium Hydroxide → 2-p-Chlorophenyl-3(3-carbomethoxypropionyl)5-propoxymethyl oxazolidine

HRID 1413324

Reaktionsgleichung

Reaktionsgleichung von HRID 1413324
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:12][CH2:11][CH:10]([CH2:13][O:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:4][CH:3]=1.[C:18]([CH2:22][CH2:23][C:24](Cl)=[O:25])([O:20][CH3:21])=[O:19].[OH-].[Na+]>C1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:12]([C:24](=[O:25])[CH2:23][CH2:22][C:18]([O:20][CH3:21])=[O:19])[CH2:11][CH:10]([CH2:13][O:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 538735082-p-Chlorophenyl-5-propoxymethyl oxazolidine

Produkt 1

HCID 202914672-p-Chlorophenyl-3(3-carbomethoxypropionyl)5-propoxymethyl oxazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To 25.6 milliliters of 25 percent w/v, 2-p-chlorophenyl-5-propoxymethyl oxazolidine solution in 50 milliliters of benzene was added 3.8 grams of 3-carbomethoxypropionyl chloride. To this reaction mixture was added 2 grams of 50% sodium hydroxide. Upon completion of the reaction solvent, benzene, was removed in vacuo. There was obtained 6.0 grams of the title compound, nD30 1.4975. Analytical data supports the structure.

Aufarbeitung

  1. customUpon completion of the reaction solvent, benzene, was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-62d50b6a99f748c8aeb5a3f311f08068
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04249931

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