Methyl 4-aminobutanoate → methyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-aminobutyrate

HRID 1413584

Reaktionsgleichung

Reaktionsgleichung von HRID 1413584
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([OH:22])=O)[C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])=[O:7])=[CH:4][CH:3]=1.[NH2:25][CH2:26][CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([NH:25][CH2:26][CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])=[O:22])[C:9]2[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:16])=[O:7])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 18614Methyl 4-aminobutanoateHCID 35383Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)-

Produkt 1

HCID 20292236methyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-aminobutyrate

Versuchsvorschrift

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyric acid and methyl 4-aminobutyrate and suitable processing produces methyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-aminobutyrate (oil), saponification of which and processing of the reaction product yields N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-aminobutyric acid (M.P. 141° to 142°).

Quellen und Nachweise

ORD-Eintrag
ord-c1138042fccb4ea1ab13d01323c9696e
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04250183

Verknüpfte Notizen

Wird geladen…