Hydrochloric Acid → 24NH2PYRIMDN,5(3MEAM4MEO5DIMEAM)BNZYL

HRID 1413733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413733
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([N:23](C)[CH3:24])[C:13]([O:21][CH3:22])=[C:14]([CH:20]=2)[N:15]([CH3:19])[C:16](=O)C)=[CH:4][N:3]=1.Cl>>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([NH:23][CH3:24])[C:13]([O:21][CH3:22])=[C:14]([N:15]([CH3:19])[CH3:16])[CH:20]=2)=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 2327657724NH2PYRMDN,5(3NME2-4MEO-5NMECOME)BENZYL

Produkt 1

HCID 2327589724NH2PYRIMDN,5(3MEAM4MEO5DIMEAM)BNZYL

Versuchsvorschrift

4.0 G. of 5'-[(2,4-diamino-5-pyrimidinyl)methyl]-3'-dimethylamino-2'-methoxy-N-methylacetanilide (prepared as described in the first paragraph of Example 2) and 100 ml. of 1-N hydrochloric acid were boiled under reflux for 2 hours. After neutralization and evaporation in vacuo, purification of the residue over silica gel with methylene chloride/propanol (8:2) and recrystallization from ethanol, there was obtained 2,4-diamino-5-[3-dimethylamino-4-methoxy-5-(methylamino)benzyl]pyrimidine, having a melting point of 183° C.

Aufarbeitung

  1. temperatureunder reflux for 2 hours
  2. customAfter neutralization and evaporation
  3. customin vacuo, purification of the residue over silica gel
  4. customwith methylene chloride/propanol (8:2) and recrystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3d4f6179dd2647568526903456bbede6
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04251454

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