Methyl iodide → 4-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate

HRID 1413950Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1413950
[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH:14]=S)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CI.[CH2:24]([NH2:36])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35].[OH-].[Na+].[C:39]([O-:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([O-:44])=[O:43]>C(Cl)(Cl)Cl>[C:39]([OH:46])(=[O:45])/[CH:40]=[CH:41]/[C:42]([OH:44])=[O:43].[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]2[CH2:13][CH2:12][N:11]([CH:14]=[N:36][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

7

Edukt 5

HCID 6328Methyl iodideHCID 13583DodecylamineHCID 14798Sodium HydroxideHCID 5460307FumarateHCID 130978784-(Diphenylmethyl)-1-piperidinecarbothioaldehyde

Produkt 1

HCID 202912264-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A solution of 5.54 g (0.019 mole) of 4-(diphenylmethyl)-1-piperidinecarbothioaldehyde in 20 ml of chloroform was treated with 2.65 g (1.16 ml, 0.019 mole) of methyl iodide and refluxed for one hour. The resulting solution was treated with 3.49 g (0.019 mole) of n-dodecylamine, refluxed one and one half hours, cooled, treated with aqueous sodium hydroxide and the organic layer separated. After drying, evaporation yielded an oil which was converted to the fumarate to yield 4-(diphenylmethyl)-1-N-(n-dodecyliminomethyl)piperidine fumarate; m.p. 143°-145.5° C.

Aufarbeitung

  1. temperaturerefluxed for one hour
  2. temperaturerefluxed one and one half hours
  3. temperaturecooled
  4. customthe organic layer separated
  5. customAfter drying
  6. customevaporation
  7. customyielded an oil which

Quellen und Nachweise

ORD-Eintrag
ord-0d6cffce02a649ea93587ddd40a8a621
Quelldatensatz
uspto-grants-1981_02
Patentnummer
US04251655

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