2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 62412-39-9

HRID 1414238Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1414238
[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([Cl:10])=[O:9])=[N:5][N:4]=1.[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[N:13]=1>O1CCOCC1>[ClH:10].[NH2:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[C:14]([N:26]2[CH2:31][CH2:30][N:29]([C:8]([C:6]3[O:7][C:3]([S:2][CH3:1])=[N:4][N:5]=3)=[O:9])[CH2:28][CH2:27]2)[N:13]=1

Komponenten

4

Edukt 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 135447285-(Methylsulfanyl)-1,3,4-oxadiazole-2-carbonyl chloride

Produkt 1

HCID 1594277762412-39-9Ausbeute 99,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

A solution of 5-methylthio-1,3,4-oxadiazole-2-carbonyl chloride (0.601 g., 3.36 mmole) in dioxane (10 ml.) was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (0.972 g., 3.36 mmole) in dioxane (100 ml.). The resultant mixture was stirred at room temperature for 65 hours, then was heated at reflux for 30 minutes. Filtration gave the title compound (1.56 g.). Recrystallization from methanol gave a product having a M.P. of 280°-285° C. with decomposition.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 30 minutes
  3. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-685cc610624c441b8623e6cf12e2104e
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04001238

Notizen zur Reaktion

Wird geladen…