5-Phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline → HCID 21486969, Verbindung

Reaktionsgleichung

[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][N:8]=[C:9]3[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:4][C:3]=2[O:2]1.[CH2:20]1[CH2:33][O:32][C:31]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][N:27]=[C:28]3[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[CH:23][C:22]=2[O:21]1>>[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][NH:8][CH:9]3[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:4][C:3]=2[O:2]1.[CH2:20]1[CH2:33][O:32][C:31]2[CH:30]=[C:29]3[C:24]([CH2:25][CH2:26][NH:27][CH:28]3[C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)=[CH:23][C:22]=2[O:21]1

Komponenten

Edukt 2

HCID 3868475-Phenyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline

HCID 21487008HCID 21487008, Verbindung

Produkt 2

HCID 21486969HCID 21486969, Verbindung

HCID 21486987HCID 21486987, Verbindung

Versuchsvorschrift

Substitution of an equivalent quantity of 6,7-methylenedioxy-1-phenyl-3,4-dihydroisoquinoline or 6,7-ethylenedioxy-1-phenyl-3,4-dihydroisoquinoline for the substituted 3,4-dihydroisoquinoline called for in the first paragraph of this example and substantial repetition of the procedure there detailed affords 6,7-methylenedioxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline, melting at about 94°-96°C., or 6,7-ethylenedioxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline, melting at about 89°-91°C., respectively.