Cyclopropanecarbonyl chloride → 1-Cyclopropancarboamide 2-(3-methoxycarbonyl-2-thioureido)-benzene

HRID 1414426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1414426
[CH:1]1([C:4](Cl)=[O:5])[CH2:3][CH2:2]1.[NH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][C:15]([NH:17][C:18]([O:20][CH3:21])=[O:19])=[S:16]>>[CH:1]1([C:4]([NH2:7])=[O:5])[CH2:3][CH2:2]1.[CH3:21][O:20][C:18]([NH:17][C:15](=[S:16])[NH:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:8]=1)=[O:19]

Komponenten

3

Edukt 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 3032830Thiophamine

Produkt 1

HCID 867343571-Cyclopropancarboamide 2-(3-methoxycarbonyl-2-thioureido)-benzene

Versuchsvorschrift

3.5g (0.033 mole) of cyclopropylcarbonylchloride were added slowly to 5.6g (0.025 mole) of 1-(2-aminophenyl)-3-methoxycarbonyl-2-thiourea in 30ml of tonuene at room temperature under agitation and the mixture was kept on reflux condition for an hour. The reaction mixture was cooled to room temperature and filtered with suction. The recovered colorless crystals were washed with water and dried. Then, by recrystallization of the crystals from the mixture of methanol and acetone, 4.2g of the crystals having the decomposition point of 191° - 192° C. were obtained.

Aufarbeitung

  1. temperatureon reflux condition for an hour
  2. filtrationfiltered with suction
  3. washThe recovered colorless crystals were washed with water
  4. customdried
  5. customThen, by recrystallization of the crystals
  6. additionfrom the mixture of methanol and acetone, 4.2g of the crystals
  7. customwere obtained

Quellen und Nachweise

ORD-Eintrag
ord-c2aa1ff2a0a944efb1c6d5a1d0e8fe14
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04001297

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