Phenylthiourea → 2-Chloroethyl [1-(3-phenylthioureido)-2-(p-chlorophenyl) ethyl]methylphosphinate

HRID 1415279

Reaktionsgleichung

Reaktionsgleichung von HRID 1415279
[PH2](=O)[O-].NC(N)=S.[CH3:8][P:9]([O:14][CH2:15][CH2:16][Cl:17])[O:10]CCCl.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH:26]=O)=[CH:21][CH:20]=1.[C:28]1([NH:34][C:35]([NH2:37])=[S:36])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:28]1([NH:34][C:35](=[S:36])[NH:37][CH:26]([P:9]([CH3:8])(=[O:10])[O:14][CH2:15][CH2:16][Cl:17])[CH2:25][C:22]2[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Komponenten

6

Edukt 5

HCID 676454PhenylthioureaHCID 2723790ThioureaHCID 4413076CID 4413076HCID 11412502(4-CHLOROPHENYL)ACETALDEHYDEHCID 14144590HCID 14144590, Verbindung

Produkt 1

HCID 537501792-Chloroethyl [1-(3-phenylthioureido)-2-(p-chlorophenyl) ethyl]methylphosphinate

Versuchsvorschrift

This example shows the preparation of a phosphinate compound, i.e., a compound having two P--C bonds. It also shows the use of a thiourea as a reactant. When equimolar quantities of bis(2-chloroethyl) methylphosphonite, p-chlorophenylacetaldehyde, and phenylthiourea are warmed at 90°-110° C for 1 hour, 2-chloroethyl [1-(3-phenylthioureido)-2-(p-chlorophenyl) ethyl]methylphosphinate is formed. Hydrolysis gives the corresponding phosphinic acid.

Quellen und Nachweise

ORD-Eintrag
ord-ccd4a847d5e843b68a0dd770090ea32c
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04003965

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