Phosphorus oxide (P4O10) → Isobutylmalonic acid di-5-indanyl ester

HRID 1415390

Reaktionsgleichung

Reaktionsgleichung von HRID 1415390
[CH2:1]([CH:5]([C:9]([OH:11])=[O:10])[C:6]([OH:8])=[O:7])[CH:2]([CH3:4])[CH3:3].[CH2:12]1[C:20]2[C:15](=[CH:16][C:17](O)=[CH:18][CH:19]=2)[CH2:14][CH2:13]1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>C1(C)C=CC=CC=1>[CH2:12]1[C:20]2[C:15](=[CH:16][C:17]([O:7][C:6](=[O:8])[CH:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:9]([O:11][C:17]3[CH:16]=[C:15]4[C:20](=[CH:19][CH:18]=3)[CH2:12][CH2:13][CH2:14]4)=[O:10])=[CH:18][CH:19]=2)[CH2:14][CH2:13]1

Komponenten

5

Edukt 3

HCID 14812Phosphorus oxide (P4O10)HCID 151185-IndanolHCID 78069Isobutylmalonic acid

Produkt 1

HCID 53699073Isobutylmalonic acid di-5-indanyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A total of 32 g of isobutylmalonic acid was boiled under reflux with 60 g of 5-indanol and 60 g of phosphorus pentoxide in 1000 ml of toluene. The solution was decanted from undissolved material and evaporated under reduced pressure. The brownish oily residue was chromatographed on a column of silica gel with benzene as the eluant. After evaporation under reduced pressure, the fractions containing the desired compound yielded 26.0 g of a light oil which crystallizes on standing to yield isobutylmalonic acid di-5-indanyl ester.

Aufarbeitung

  1. customThe solution was decanted from undissolved material
  2. customevaporated under reduced pressure
  3. customThe brownish oily residue was chromatographed on a column of silica gel with benzene as the eluant
  4. customAfter evaporation under reduced pressure
  5. additionthe fractions containing the desired compound
  6. customyielded 26.0 g of a light oil which
  7. customcrystallizes

Quellen und Nachweise

ORD-Eintrag
ord-bdcbbd59ed624f3f8dd792c27200af9b
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04005073

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