Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

HRID 1415478

Reaktionsgleichung

Reaktionsgleichung von HRID 1415478
Cl.[CH3:2][O:3][NH2:4].C(N(CC)CC)C.[CH:12]1([N:22]=[C:23]=[S:24])[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1>C(Cl)Cl>[CH3:2][O:3][NH:4][C:23]([NH:22][CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14][CH2:13]1)=[S:24]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 213934781-Isothiocyanato-1,2,3,4-tetrahydronaphthalene

Produkt 1

HCID 213934961-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.

Aufarbeitung

  1. additionis added dropwise
  2. filtrationfiltered
  3. washThe filtrate is washed with water
  4. dry with materialdried (sodium sulfate)
  5. customthe solvent evaporated at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fe2c7237231b464bbce50bf2fe5a121f
Quelldatensatz
uspto-grants-1977_01
Patentnummer
US04005140

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