Dimethylformamide → 2-Nitro-5-[(pyrimidin-2-yl)sulfanyl]aniline

Beteiligte Stoffe

Reaktionsschritte

A mixture of 3.5 g. of 2-amino-4-chloro-1-nitrobenzene, 5.5 g. of potassium carbonate, and 4.5 g. of 2-mercaptopyrimidine in 25 ml. dimethylformamide is heated overnight under nitrogen at 105°-110° C. The mixture is cooled, diluted with water and the product filtered off. Recrystallization from methanol yields 2-amino-1-nitro-4-(pyrimidin-2-ylthio)benzene.

Herkunft & Nachweise