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Tetrahydrofuran → 2-(2-benzyloxyethyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1-p-nitrobenzyl-1H-imidazole

HRID 1416065
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1416065
[CH2:1]([O:8][CH2:9][CH2:10][C:11]1[NH:12][C:13]([S:19][C:20]2[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[CH:21]=2)=[C:14]([CH:16]([CH3:18])[CH3:17])[N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].[N+:30]([CH:33](Br)[C:34]1C=CC=C[CH:35]=1)([O-:32])=[O:31].O1[CH2:45][CH2:44][CH2:43][CH2:42]1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:1]([O:8][CH2:9][CH2:10][C:11]1[N:12]([CH2:42][C:43]2[CH:35]=[CH:34][C:33]([N+:30]([O-:32])=[O:31])=[CH:45][CH:44]=2)[C:13]([S:19][C:20]2[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[CH:21]=2)=[C:14]([CH:16]([CH3:18])[CH3:17])[N:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 11356361NitrobenzylbromideHCID 178440093HCID 178440093, Verbindung

Produkt 1

HCID 178907742-(2-benzyloxyethyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1-p-nitrobenzyl-1H-imidazoleAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 74236Tetrabutylammonium BromideKatalysator

Versuchsvorschrift

In 10 ml of tetrahydrofuran was dissolved 1.05 mg (2.5 mmol)of 2-(2-benzyloxyethyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1H-imidazole (Compound I-136), followed by addition of 220 mg (5.5 mmol)of sodium hydroxide, 48 mg (0.15 mmol) of tetrabutylammonium bromide and 594 mg (2.75 mmol)of nitrobenzylbromide with stirring at room temperature, and the mixture was reacted for 3 hours and worked up. The reaction mixture was distilled off under reduced pressure, and the residue was extracted with ethyl acetate. The extract was washed with water, dried, and the solvent was distilled off. The residue was purified by silica gel column chromatography (ethyl acetate:chloroform=1:9)to give 1.3 g (93%)of 2-(2-benzyloxyethyl)-5-(3,5-dichlorophenylthio)-4-isopropyl-1-p-nitrobenzyl-1H-imidazole (125a)as oil.

Aufarbeitung

  1. customthe mixture was reacted for 3 hours
  2. distillationThe reaction mixture was distilled off under reduced pressure
  3. extractionthe residue was extracted with ethyl acetate
  4. washThe extract was washed with water
  5. customdried
  6. distillationthe solvent was distilled off
  7. customThe residue was purified by silica gel column chromatography (ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-456d327a88bd435d87cdc5b71e1c559b
Quelldatensatz
uspto-grants-1999_06
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05910506

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