Triethylamine → 4-[4-[(6-Bromoimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzamide

Beteiligte Stoffe

Reaktionsschritte

Following the general procedure of Example 2, Step 3, and making noncritical variations, 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (Example 15, Step 1; 0.252 g), 4-(piperazin-1-yl)benzamide (Example 3, Step 1; 0.211 g), triethylamine (0.104 g), and ethylene glycol (2 mL) give 0.206 g of the title compound after crystallization from methanol/dichloromethane/hexane; mp 238-239° C.; MS m/z 413,415; IR (mineral oil) 1612, 1656, 3379, 1331, 1240 cm-1. 1H NMR (DMSO-d6) δ2.60, 3.25, 3.66, 6.92, 7.04, 7.32, 7.49, 7.71, 7.73, 7.83, 8.87.

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