5,6-Dimethylbenzimidazole → 1H-Furo[3,4-f]benzimidazole-5,7-dione

Reaktionsgleichung

[N:1]1[C:5]2[CH:6]=[C:7]([C:13]([OH:15])=[O:14])[C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[NH:3][CH:2]=1.CC1C(C)=CC2N=CNC=2C=1>>[N:3]1[C:4]2[CH:9]=[C:8]3[C:10](=[O:12])[O:15][C:13](=[O:14])[C:7]3=[CH:6][C:5]=2[NH:1][CH:2]=1

Komponenten

Edukt 2

HCID 6755,6-Dimethylbenzimidazole

HCID 7023591Benzimidazole-5,6-dicarboxylic acid

Produkt 1

HCID 108452781H-Furo[3,4-f]benzimidazole-5,7-dioneAusbeute 81,5 %

Reaktionsbedingungen

Temperatur: 250 °C

Versuchsvorschrift

Benzimidazole-5,6-dicarboxylic acid (8.2 g), prepared from 5,6-dimethylbenzimidazole as described in J.Org.Chem. 1987, 52, 2934., was heated at 250° C. under vacuum (0.01 mm Hg) for 1 h. The solid was extracted with hot acetone and the acetone extracts were evaporated to give the title compound (6.1 g).

Aufarbeitung

extractionThe solid was extracted with hot acetone
customthe acetone extracts were evaporated

Quellen und Nachweise

ORD-Eintrag: ord-8d039b3793844ab9a102886c2463afb6
Quelldatensatz: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05912260

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