Hydrochloride methanol → HCID 67581958, Verbindung
Reaktionsgleichung
C(O)(=O)C.[OH:5][C@@H:6]1[CH2:10][O:9][CH2:8][C@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:13]=1.[ClH:28].CO>CC(C)=O>[ClH:28].[OH:5][C@@H:6]1[CH2:10][O:9][CH2:8][C@H:7]1[O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]([N:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2)[N:13]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (cf. Example 12) (150 mg) in acetone (10 ml) is added 2N HCl-methanol (0.26 ml), and the mixture is evaporated to dryness under reduced pressure, and the residue is washed with acetone. The obtained crystals are recrystallized from methanol-acetone to give 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline monohydrochloride (96 mg) as crystals.