Ethanolamine → HCID 15749831, Verbindung

HRID 1416681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1416681
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[N:13]=[C:12](Cl)[C:11]=2[CH:10]=[CH:9]1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20]2[C:19]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:21])[C:14]=3[N:13]=[C:12]([NH:26][CH2:25][CH2:23][OH:24])[C:11]=2[CH:10]=[CH:9]1

Komponenten

3

Edukt 2

HCID 700EthanolamineHCID 157498291-(2-Methylphenyl)-4-chloro-6-methylpyrrolo[3,2-c]quinoline

Produkt 1

HCID 15749831HCID 15749831, Verbindung

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

1-(2-methylphenyl)-4-chloro-6-methylpyrrolo [3,2-c]quinoline (306 mg, 1.0 mmol) was dissolved in 10 ml of ethanolamine in a pressure tube and heated at 150° C. for 3 hours. After removal of the reaction solvent under reduced pressure and diluted in 20 ml of methylene chloride, the residue was dried by anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography to obtain 236 mg of desired compound as solid in 72% of yield.

Aufarbeitung

  1. customAfter removal of the reaction solvent under reduced pressure
  2. additiondiluted in 20 ml of methylene chloride
  3. dry with materialthe residue was dried by anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-f02db5a3ab7d40598ba37556055dda87
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05914402

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