Hydrochloric Acid → HCID 86754129, Verbindung

HRID 1416724

Reaktionsgleichung

Reaktionsgleichung von HRID 1416724
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:29])[CH2:9][NH:10][CH:11]([CH3:28])[CH2:12][C:13]2[CH:27]=[CH:26][C:16]3[O:17][C:18]([C:23]([OH:25])=[O:24])([C:20]([OH:22])=[O:21])[O:19][C:15]=3[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[O:30]([CH2:37][CH2:38]O)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.Cl>>[ClH:1].[O:17]([CH2:18][CH2:20][O:24][C:23]([C:18]1([C:20]([O:22][CH2:38][CH2:37][O:30][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)=[O:21])[O:17][C:16]2[CH:26]=[CH:27][C:13]([CH2:12][CH:11]([NH:10][CH2:9][CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[OH:29])[CH3:28])=[CH:14][C:15]=2[O:19]1)=[O:25])[C:16]1[CH:26]=[CH:27][CH:13]=[CH:14][CH:15]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 31236PhenoxyethanolHCID 42813555-{2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid

Produkt 1

HCID 86754129HCID 86754129, Verbindung

Versuchsvorschrift

The title compound was prepared from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-phenoxyethanol according to the procedure of Example 1 as an off-white gummy solid; 1H NMR (300 MHz, CDCl3): δ 1.23-1.40 (brs, 3H), 2.70-2.90 (brm, 1H), 3.05-3.30 (brm, 2H), 3.31-3.52 (brm, 2H), 4.12 (t, J=4.4 Hz, 4H), 4.57 (t, J=4.8 Hz, 4H), 5.38-5.60 (brs, 2H), 6.70-7.0 (complexm, 10H), 7.15-7.47 (complex m, 7H), 8.60-8.80 (brs, 1H), 9.90-10.20 (brs, 1H).; MS (ES) m/z (relative intensity): 662 (M+ -HCl, (100), 594 (20), 498 (35).

Quellen und Nachweise

ORD-Eintrag
ord-859cf38e77544f8f8baaa04f71386f21
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05914339

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