8-Cyano-octanoic acid → 9-Aminononanoic acid

HRID 1417049

Reaktionsgleichung

Reaktionsgleichung von HRID 1417049
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])#[N:2]>C(O)(C)C.N.[Co]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Komponenten

5

Edukt 1

HCID 110843008-Cyano-octanoic acid

Produkt 1

HCID 1368779-Aminononanoic acidAusbeute 92,5 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 104730CobaltKatalysatorHCID 222AmmoniaLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

84.5 g of 8-cyanooctanoic acid dissolved in 500 ml of isopropyl alcohol saturated with NH3 are hydrogenated at 50° C. and 80 bar for 3 hours, using 20 g of cobalt-Raney as catalyst. The catalyst is filtered out and the solution is concentrated. Cooling and purification produce 9-aminononanoic acid (80 g) in the form of a crystalline solid product with a m.p. of 190-192° C.

Aufarbeitung

  1. customare hydrogenated at 50° C.
  2. filtrationThe catalyst is filtered out
  3. concentrationthe solution is concentrated
  4. temperatureCooling
  5. custompurification

Quellen und Nachweise

ORD-Eintrag
ord-1b028e65be614122ad30c0bf9ba1a2f2
Quelldatensatz
uspto-grants-1999_06
Patentnummer
US05917067

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