Hydrazine → HCID 54501591, Verbindung

HRID 1417315Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1417315
[N:1]1([C:6]2[CH:27]=[CH:26][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]3C(=O)C4C(=CC=CC=4)C3=O)=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.NN>C(O)C>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[CH:26][CH:27]=2)[CH:5]=[N:4][N:3]=[N:2]1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 67598186HCID 67598186, Verbindung

Produkt 1

HCID 54501591HCID 54501591, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of 19.4 g of 2-[4-[4-(1H-tetrazol-1-yl)phenoxy]butyl]-1H-isoindole-1,3(2H)-dione (Example 38) in 400 ml boiling ethanol is treated with 3 ml of anhydrous hydrazine, and the mixture stirred at reflux for 16 hours. The precipitate is collected, washed with 200 ml of hot 1.5N HCl, and 50 ml of H2O. The combined ethanol, hydrochloric acid, and water filtrates are taken to dryness in vacuo to give the hydrochloride salt of the title compound. A portion of the salt was recrystallized from hot ethanol, m.p. 197°-198° C. (dec.).

Aufarbeitung

  1. temperatureat reflux for 16 hours
  2. customThe precipitate is collected
  3. washwashed with 200 ml of hot 1.5N HCl, and 50 ml of H2O

Quellen und Nachweise

ORD-Eintrag
ord-be7bda1fb04847e8bc6a9ba5b9f71bbd
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05877196

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