Hydrochloric Acid → 8-Amino-octanoic acid methyl-butyl-amide

HRID 1417420Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1417420
[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11]C(OC(C)(C)C)=O.Cl>O1CCOCC1>[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

Produkt 1

HCID 541906878-Amino-octanoic acid methyl-butyl-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Combine 8-(t-butoxycarbonyl)amino-octanoic acid methyl-butyl-amide and 4M hydrochloric acid in dioxane (10 mL). After 1 hour, the reaction mixture is evaporated to a residue. Partition the residue between toluene and 1M sodium hydroxide solution. Extract the aqueous layer with toluene. Combine the organic layers, dry over MgSO4, and filter to give the title compound as a toluene solution. Evaporate in vacuo to give the title compound.

Aufarbeitung

  1. customthe reaction mixture is evaporated to a residue
  2. customPartition the residue between toluene and 1M sodium hydroxide solution
  3. extractionExtract the aqueous layer with toluene
  4. dry with materialdry over MgSO4
  5. filtrationfilter

Quellen und Nachweise

ORD-Eintrag
ord-1fb774483c154405bca8f0fa6a4001ad
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05877202

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