3-Chloro-N,N-dimethyl-1-propanamine → 4-[4'-(3-Dimethylaminopropoxy)anilino]6-(3'-methylanilino)pyrimidine

HRID 1417991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1417991
[OH:1][C:2]1[CH:22]=[CH:21][C:5]([NH:6][C:7]2[CH:12]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=3)[N:10]=[CH:9][N:8]=2)=[CH:4][CH:3]=1.[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27]Cl>>[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27][O:1][C:2]1[CH:22]=[CH:21][C:5]([NH:6][C:7]2[CH:12]=[C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=3)[N:10]=[CH:9][N:8]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 544096924-[4'-Hydroxyanilino]6-(3'-methylanilino)pyrimidine

Produkt 1

HCID 670151294-[4'-(3-Dimethylaminopropoxy)anilino]6-(3'-methylanilino)pyrimidineAusbeute 13 %

Versuchsvorschrift

Using an analogous reaction procedure to that described in Example 23, 4-(4'-hydroxyanilino)-6-(3'-methylanilino)pyrimidine (0.6 g) was reacted with 3-dimethylaminopropyl chloride. The product so obtained was chromatographed on silica and precipitated from a mixture of methylene chloride, methanol and hexane to give 4-[4'-(3-dimethylaminopropoxy)anilino]6-(3'-methylanilino)pyrimidine in 13% yield, m.p. 204°-207° C.;

Aufarbeitung

  1. customan analogous reaction procedure to
  2. customThe product so obtained
  3. customwas chromatographed on silica
  4. customprecipitated from a mixture of methylene chloride, methanol and hexane

Quellen und Nachweise

ORD-Eintrag
ord-d342c866d34d4b95af4520f8fe6b1e39
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05880130

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