Sodium Hydroxide → 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

HRID 1418719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1418719
CC(C)(C)C([O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)=[CH:8][C:7]=1[Cl:18])=O.[OH-].[Na+]>C(O)C>[Cl:18][C:7]1[CH:8]=[C:9]([CH2:12][N:13]2[N:17]=[CH:16][CH:15]=[N:14]2)[CH:10]=[CH:11][C:6]=1[OH:5]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 53869820HCID 53869820, Verbindung

Produkt 1

HCID 218336772-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 3 g of 2-chloro-4-(2-2H-1,2,3-triazolyl)methylphenyl 2,2-di-methylpropanoate, 10 ml of 20% aqueous sodium hydroxide solution and 60 ml of ethanol was heated at reflux for 5 hours. The reaction mixture was then concentrated under reduced pressure, to which water was added, and the mixture was adjusted to pH 6.0 with concentrated hydrochloric acid. This mixture was extracted with ethyl acetate. The organic layer was washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, which afforded 2-chloro-4-(2-2H-1,2,3-triazolylmethyl)phenol.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. concentrationThe reaction mixture was then concentrated under reduced pressure, to which water
  4. additionwas added
  5. extractionThis mixture was extracted with ethyl acetate
  6. washThe organic layer was washed with water
  7. dry with materialdried with anhydrous magnesium sulfate
  8. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-78d26d8ca1f74a78be6a2dd0d6b84b36
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05883262

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