Hydrochloric Acid → 3-(4-diallylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride

HRID 1418958Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1418958
[CH2:1]([N:4]([CH2:8][C:9]1[N:10]=[C:11]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=4[C:21](=[O:29])[N:20]([CH3:30])[CH2:19][C:18]=23)[S:12][CH:13]=1)[CH2:5][CH:6]=[CH2:7])[CH:2]=[CH2:3].[ClH:31]>C(O)C>[ClH:31].[CH2:1]([N:4]([CH2:8][C:9]1[N:10]=[C:11]([C:14]2[N:15]=[CH:16][N:17]3[C:23]4[CH:24]=[CH:25][C:26]([F:28])=[CH:27][C:22]=4[C:21](=[O:29])[N:20]([CH3:30])[CH2:19][C:18]=23)[S:12][CH:13]=1)[CH2:5][CH:6]=[CH2:7])[CH:2]=[CH2:3]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 218422383-(4-diallylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

Produkt 1

HCID 218422373-(4-diallylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochlorideAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

0.90 g (0.00212 mol) of 3-(4-diallylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]-benzodiazepin-6-one in 40 ml of ethanol was treated with 0.45 ml (0.00215 mol) of 4.78N ethanolic hydrochloric acid. After stirring at room temperature for 15 minutes the solution obtained was completely freed from the solvents. The residue was recrystallized from ethanol/ether. There was obtained 0.78 g (80%) of 3-(4-diallylaminomethyl-thiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one hydrochloride (1:1) as white crystals; m.p. 152°-155°.

Aufarbeitung

  1. customobtained
  2. customThe residue was recrystallized from ethanol/ether

Quellen und Nachweise

ORD-Eintrag
ord-22339b871ed049e4905d9d8436873668
Quelldatensatz
uspto-grants-1999_03
Patentnummer
US05885986

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