4-Chloropyridinium chloride → HCID 11243907, Verbindung

HRID 1420769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1420769
CO[C:3]1(OC)[CH2:7][CH2:6][CH2:5]O1.[Cl-].ClC1C=C[NH+]=CC=1.[NH2:18][C:19]1[C:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])=[CH:22][S:21][C:20]=1[C:32]([O:34][CH3:35])=[O:33]>O1CCOCC1>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:23]1[C:19]([N:18]2[CH:3]=[CH:7][CH:6]=[CH:5]2)=[C:20]([C:32]([O:34][CH3:35])=[O:33])[S:21][CH:22]=1

Komponenten

5

Edukt 3

HCID 108772904-Chloropyridinium chlorideHCID 11311579HCID 11311579, VerbindungHCID 11788317Dimethoxytetrahydrofurane

Produkt 1

HCID 11243907HCID 11243907, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

5.2 mmol of dimethoxytetrahydrofuran and 5.2 mmol of 4-chloropyridinium chloride in 100 ml of dioxane are stirred for 15 minutes at ambient temperature and then 5.2 mmol of the compound obtained in Step C are added. The reaction mixture is then heated at reflux of the solvent for 3 hours and subsequently filtered. After concentrating the filtrate under reduced pressure, the residue obtained is crystallised by trituration in ethyl ether, allowing the expected product to be isolated.

Aufarbeitung

  1. temperatureThe reaction mixture is then heated
  2. temperatureat reflux of the solvent for 3 hours
  3. filtrationsubsequently filtered
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue obtained
  6. customis crystallised by trituration in ethyl ether
  7. customto be isolated

Quellen und Nachweise

ORD-Eintrag
ord-26cb5e0cfa7247b680d4ed77986e50ee
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06071945

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