Avermectin → Ivermectin CRS

Beteiligte Stoffe

Reaktionsschritte

4.3 g of avermectin (B1a and B1b mixture) are, after addition of 53.2 mg of tris-(octylphenyl)-phosphine, hydrogenated using the conditions given in Example 1 (B). After a hydrogenation time of 7 hours, a crude ivermectin product is obtained which, according to HPLC analysis, contains 1.3% of avermectin, 94.8% of ivermectin and 2% of tetrahydroavermectin.

Herkunft & Nachweise