Imidazole → 2-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

HRID 1421725Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1421725
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[C:5]([OH:11])[CH:4]=1.[NH:12]1[CH:16]=[CH:15][N:14]=[CH:13]1>CN(C=O)C>[OH:11][C:5]1[CH:4]=[C:3]([CH2:2][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)[CH:10]=[CH:9][C:6]=1[C:7]#[N:8]

Komponenten

4

Edukt 2

HCID 795ImidazoleHCID 216969934-(Bromomethyl)-2-hydroxybenzonitrile

Produkt 1

HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Bromomethyl-2-hydroxybenzonitrile (0.222 g, 1.045 mmol) and imidazole (0.356 g, 5.23 mmol) were stirred in DMF (10 mL) at ambient temperature for 18 hr. The reaction mixture was concentrated in vacuo to remove the DMF, and the residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2) to give the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto remove the DMF
  3. customthe residue was chromatographed (SiO2, 2-5% CH3OH in CH2Cl2)

Quellen und Nachweise

ORD-Eintrag
ord-570b20861e5e454a9d7a4d8f0351e9aa
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06077853

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