Ethanol → HCID 385223, Verbindung

HRID 1421871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1421871
OC[CH:3]([NH2:8])[CH:4]1[CH2:7][CH2:6][CH2:5]1.[NH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1.[CH2:18]([OH:20])C>C(N(CC)CC)C>[NH2:9][C:10]1[N:15]=[C:14]([NH:8][CH2:3][C:4]2([CH2:18][OH:20])[CH2:5][CH2:6][CH2:7]2)[CH:13]=[C:12]([Cl:17])[N:11]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 655222-Amino-4,6-dichloropyrimidineHCID 15458387HCID 15458387, Verbindung

Produkt 1

HCID 385223HCID 385223, VerbindungAusbeute 92,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

A mixture of 1-hydroxymethyl-1-cyclobutylmethylamine (5.75 g, 0.05 mol), 2-amino-4,6-dichloropyrimidine (8.20 g, 0.05 mol), ethanol (200 ml) and triethylamine (20 ml) was refluxed for one day. The solvent was distilled away under reduced pressure. The residue was washed with water, dried and recrystallized from acetone to give colorless prism crystals (11.2 g, 92.3%), m.p. 192-194° C. (acetone).

Aufarbeitung

  1. temperaturewas refluxed for one day
  2. distillationThe solvent was distilled away under reduced pressure
  3. washThe residue was washed with water
  4. customdried
  5. customrecrystallized from acetone

Quellen und Nachweise

ORD-Eintrag
ord-2da758854a624c0887b4f377db1896d1
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06080750

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