Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1422056Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1422056
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 145174-Fluorobenzonitrile

Produkt 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochlorideAusbeute 92 %

Versuchsvorschrift

Into a solution of 4-fluorobenznitrile (50.9 g, 0.420 mol) in ethanol (500 mL) was blown hydrogen chloride to saturation under ice-cooling and the mixture was stirred at room temperature for 21 hours. The solvent was evaporated under reduced pressure and the obtained crystals were washed with ether and dried in vacuo to give ethyl 4-fluorobenzimidate hydrochloride as white crystals (78.8 g, 92%).

Aufarbeitung

  1. temperaturecooling
  2. customThe solvent was evaporated under reduced pressure
  3. washthe obtained crystals were washed with ether
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-21e48446e8d948debcdc37e22b76d4f5
Quelldatensatz
uspto-grants-2000_06
Patentnummer
US06080738

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