Potassium Carbonate → 1-isobutyl-3-methyl-6-(4-(pyridin-2-yl)benzyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

HRID 1422998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1422998
[CH2:1]([N:5]1[C:10]2=[CH:11][NH:12][CH:13]=[C:9]2[C:8](=[O:14])[N:7]([CH3:15])[C:6]1=[O:16])[CH:2]([CH3:4])[CH3:3].Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)=[CH:21][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:1]([N:5]1[C:10]2=[CH:11][N:12]([CH2:18][C:19]3[CH:20]=[CH:21][C:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=4)=[CH:23][CH:24]=3)[CH:13]=[C:9]2[C:8](=[O:14])[N:7]([CH3:15])[C:6]1=[O:16])[CH:2]([CH3:4])[CH3:3]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 98875912-(4-Bromomethylphenyl)pyridineHCID 674156251-isobutyl-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Produkt 1

HCID 674162921-isobutyl-3-methyl-6-(4-(pyridin-2-yl)benzyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A suspension of 1-isobutyl-3-methyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (100 mg, 0.45 mmol), 2-(4-(bromomethyl)phenyl)pyridine (160 mg, 0.65 mmol) and potassium carbonate (120 mg, 0.87 mmol) in anhydrous DMF is stirred at room temperature overnight. After routine workup, the obtained crude product is purified by a semi-preparative HPLC to give pure product as white solids. MS (ESI) m/z 389.2 [M+H]+.

Aufarbeitung

  1. customAfter routine workup, the obtained crude product
  2. customis purified by a semi-preparative HPLC
  3. customto give pure product as white solids

Quellen und Nachweise

ORD-Eintrag
ord-9710a04e92124c76a69277e6c25ebc59
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927556B2

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