HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Methyl-2-butene → 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Methyl-2-butene | HCID 10553 | — |
| Edukt | Sodium Chlorite | HCID 23668197 | — |
| Edukt | Monosodium phosphate | HCID 23672064 | — |
| Edukt | 5-Methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde | HCID 86648481 | — |
| Produkt | 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid | HCID 67549808 | 118,2% |
Reaktionsschritte
The same operation as in Example (33c) was performed using 5-methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (36c) (90 mg, 0.51 mmol), sodium chlorite (95 mg, 1.05 mmol), sodium dihydrogenphosphate (154 mg, 0.99 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117 mg of the title compound as a white solid (100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08927588B2 |
| Quelldatensatz | uspto-grants-2015_01 |
| ORD ID | ord-f0ba857fc62649d79a7c8e3e65bf1df2 |
| Quellennotiz | uspto-grants-2015_01 |