Ammonia → 2-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

HRID 1424943Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1424943
[CH2:1]1[C:6](=O)[N:5](Cl)[C:3](=O)[CH2:2]1.[F:9][C:10]([F:22])([F:21])C(C1(CC)SCCCS1)=O.[CH3:23][O:24][CH:25]([O:28][CH3:29])[CH:26]=O.[NH3:30]>[N+]([O-])([O-])=O.[Ag+]>[CH3:23][O:24][CH:25]([O:28][CH3:29])[C:26]1[NH:30][C:2]([CH2:1][CH3:6])=[C:3]([C:10]([F:22])([F:21])[F:9])[N:5]=1

Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 31398ChlorosuccinimideHCID 162650Acetaldehyde, 2,2-dimethoxy-HCID 866484862,2,2-Trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone

Produkt 1

HCID 684060432-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24470Silver NitrateKatalysator

Versuchsvorschrift

The same operation as in Example (36b) was performed using NCS (1.35 g, 10.1 mmol), silver nitrate (2.45 g, 14.4 mmol), 2,2,2-trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone obtained in Example (39b) (1.0 g, 4.09 mmol), dimethoxyacetaldehyde (5.76 M aqueous solution, 1.0 mL, 5.76 mmol) and 28% aqueous ammonia (4 mL). The resulting compound was used for the next reaction without purification.

Aufarbeitung

  1. customThe resulting compound was used for the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-32c9d6fbc87e4f1f88b22aa950396e18
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927588B2

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