2-Methyl-2-butene → 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid

Beteiligte Stoffe

Reaktionsschritte

The same operation as in Example (33c) was performed using 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (39d) (110 mg, 0.57 mmol), sodium chlorite (108 mg, 1.19 mmol), sodium dihydrogenphosphate (178 mg, 1.14 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117.5 mg of the title compound as a white solid (99%).

Herkunft & Nachweise