Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-propoxypiperidin-1-yl)benzoate → HCID 86648740, Verbindung

HRID 1425257Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1425257
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:28][CH2:29][CH2:30][CH3:31])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:28][CH2:29][CH2:30][CH3:31]

Komponenten

3

Edukt 1

HCID 86648737Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-propoxypiperidin-1-yl)benzoate

Produkt 1

HCID 86648740HCID 86648740, VerbindungAusbeute 81,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418390HCID 178418390, VerbindungKatalysator

Versuchsvorschrift

The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-propoxypiperidin-1-yl)benzoate obtained in Example (178a) (78 mg, 0.18 mmol) and a 10% palladium-carbon catalyst (100 mg), to obtain 42.8 mg of the title compound as a pale yellow oily substance (80%). The resulting compound was used for the next reaction without purification.

Quellen und Nachweise

ORD-Eintrag
ord-2bc6a9375df644e5a230faf28a98c670
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927588B2

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