7-Bromo-1-Chloroisoquinoline → 7-bromo-2-(N-propylamino)isoquinoline

HRID 14256

Reaktionsgleichung

Reaktionsgleichung von HRID 14256
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(N)CC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([NH:8][CH2:7][CH2:6][CH3:5])[CH2:9]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 65020247-Bromo-1-Chloroisoquinoline

Produkt 1

HCID 210859967-bromo-2-(N-propylamino)isoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7852PropylamineLösungsmittel

Versuchsvorschrift

A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. dissolutiondissolved in chloroform
  3. washwashed with saturated sodium bicarbonate, saturated sodium chloride
  4. dry with materialdried (sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d4e7541abda242baa613fc8098349853
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727997B2

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