Isopropanol → HCID 86619830, Verbindung

HRID 1426872Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1426872
[C:1]([O:5][C:6]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[CH:9]=[C:8]([F:15])[CH:7]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH:23]([OH:26])([CH3:25])[CH3:24]>>[CH:23]([O:26][C:13](=[S:14])[NH:12][C:10]1[CH:9]=[C:8]([F:15])[CH:7]=[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH:11]=1)([CH3:25])[CH3:24]

Komponenten

4

Edukt 3

HCID 3776IsopropanolHCID 8471TriethylamineHCID 86619831HCID 86619831, Verbindung

Produkt 1

HCID 86619830HCID 86619830, Verbindung

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1-tert-Butoxy-3-fluoro-5-isothiocyanatobenzene (24.0 g) and triethylamine (10.9 g) are dissolved in iso-propanol (150 ml). The reaction mixture is refluxed for 18 hours and the solvent is removed by vacuo. The crude product is dissolved in hexane: diethyl ether (19:1). The diethyl ether is removed in vacuo and the solution is cooled to 0° C. for 3 hours. The solution is filtered to give the title compound.

Aufarbeitung

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. customthe solvent is removed by vacuo
  3. dissolutionThe crude product is dissolved in hexane: diethyl ether (19:1)
  4. customThe diethyl ether is removed in vacuo
  5. filtrationThe solution is filtered

Quellen und Nachweise

ORD-Eintrag
ord-e9c21e0a133d41aab1374f00b10ed18f
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08933108B2

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