Potassium Hydroxide → Potassium 6-chloro-3-methyl-pyridine-2-carboxylate

HRID 1427071Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1427071
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([O:10]C)=[O:9])[C:5]([CH3:12])=[CH:4][CH:3]=1.[OH-].[K+:14]>C(O)(C)C>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([O-:10])=[O:9])[C:5]([CH3:12])=[CH:4][CH:3]=1.[K+:14]

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 45489870Methyl 6-chloro-3-methylpyridine-2-carboxylate

Produkt 1

HCID 86707308Potassium 6-chloro-3-methyl-pyridine-2-carboxylateAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Methyl 6-chloro-3-methyl-pyridine-2-carboxylate (50 g, 269.4 mmoles) is added to a solution of potassium hydroxide (18.7 g, 282.9 mmoles) in isopropyl alcohol (2000 mL). The mixture is stirred at ambient temperature for 1 hour. Hexanes (500 mL) are added, and the solid is filtered, washed with hexanes, and dried under reduced pressure at 45° C. for 4 hours to give the title compound (52 g, 92%). Mass spectrum (m/z): 172.0 (M+1). 1H NMR (300 MHz, D2O): 7.62 (d, J=8.0 Hz, 1H), 7.27 (d, J=8.0 Hz, 1H), 2.23 (s, 3H).

Aufarbeitung

  1. filtrationthe solid is filtered
  2. washwashed with hexanes
  3. customdried under reduced pressure at 45° C. for 4 hours

Quellen und Nachweise

ORD-Eintrag
ord-df6cc4ca40044d708fffc2af29e0f1de
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08933098B2

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