methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate → methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

HRID 1427230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1427230
C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20])=O)(C)(C)C>Cl.CO>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[N:12][N:13]2[C:18]([C:25]1[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=1)([CH2:23][CH3:24])[C:19]([O:21][CH3:22])=[O:20]

Komponenten

3

Edukt 1

HCID 70562967methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

Produkt 1

HCID 70561351methyl 2-(4-amino-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21893726Hydrochloride methanolLösungsmittel

Versuchsvorschrift

A mixture of methyl 2-(4-(tert-butoxycarbonylamino)-1H-indazol-1-yl)-2-(4-chlorophenyl)butanoate (3.0 g, 6.8 mmol), as described in Example 18 Step D, in 4 N HCl/MeOH (20 mL) was stirred at room temperature for 2 h. After removing the solvent, the residue was dissolved in ethyl acetate (80 mL), pH value adjusted to 9-10 with saturated sodium bicarbonate solution, dried over sodium sulfate, then filtered. After removing the organic solvent, the residue was used for the next step without purification. LC/MS m/z=344.1 [M+H]+.

Aufarbeitung

  1. customAfter removing the solvent
  2. dissolutionthe residue was dissolved in ethyl acetate (80 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customAfter removing the organic solvent
  6. customthe residue was used for the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-e065240689d4441986da8b415d686027
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08933113B2

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