Hydrogen Bromide → 4'-Bromomethyl-4-decyloxybiphenyl

HRID 1428

Reaktionsgleichung

Reaktionsgleichung von HRID 1428
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[BrH:26]>>[Br:26][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 260Hydrogen BromideHCID 190699634-Hydroxymethyl-4'-decyloxybiphenyl

Produkt 1

HCID 190699574'-Bromomethyl-4-decyloxybiphenyl

Versuchsvorschrift

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

Aufarbeitung

  1. customAfter completion of the reaction
  2. extractionthe resultant mixture was extracted with ether
  3. washwashed with water, which
  4. washwas further washed with an aqueous solution
  5. additioncontaining saturated NaHCO3
  6. washwashed again with water
  7. concentrationThe reaction product was concentrated
  8. customseparated by colomun chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3104bd09c2f7414fbbfc325719b77c64
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05725798

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