(S)-1-(2,4-Difluorophenyl)ethanamine → HCID 67152322, Verbindung

HRID 1428191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1428191
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([C:10]2[CH:11]=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=23)[CH:3]=1.[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C@@H:27]([NH2:29])[CH3:28]>CN1C(=O)CCC1>[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C@@H:27]([NH:29][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=23)[N:5]=[C:6]([S:8][CH3:9])[N:7]=1)[CH3:28]

Komponenten

4

Edukt 2

HCID 2060581(S)-1-(2,4-Difluorophenyl)ethanamineHCID 58268975HCID 58268975, Verbindung

Produkt 1

HCID 67152322HCID 67152322, VerbindungAusbeute 58,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

A 7 ml NMP solution of 3-(6-chloro-2-(methylthio)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidine (7h, 1.30 g) and (S)-1-(2,4-difluoro-phenyl)ethanamine (1.47 g) was heated in a microwave reactor at 220° C. for 20 min. LC/MS indicated the major peak was the desired product. The reaction mixture was partitioned between ethyl acetate and sat. NH4OAc. The organic phase was dried with MgSO4, filtered and the solvent was removed under reduced pressure. The product was purified by chromatography (SiO2, EtOAc-Hex, 1:1) (1.09 g, 58.6% yield).

Quellen und Nachweise

ORD-Eintrag
ord-2d55575e489d4b5e846bc867470d3144
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937064B2

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