5,6,7,8-Tetrahydro-2-naphthylamine → 1-(4-oxo-3,4,6,7,8,9-hexahydro-benzo[g]quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 1428855

Reaktionsgleichung

Reaktionsgleichung von HRID 1428855
C1C2CCCCC=2C=CC=1N.[CH2:12]([O:14][C:15]([C:17]1[CH:18]=[N:19][N:20]([C:22]2[NH:31][C:30](=[O:32])[C:29]3[C:28]4[CH2:33][CH2:34][CH2:35][CH2:36][C:27]=4[CH:26]=[CH:25][C:24]=3[N:23]=2)[CH:21]=1)=[O:16])[CH3:13]>>[CH2:12]([O:14][C:15]([C:17]1[CH:18]=[N:19][N:20]([C:22]2[NH:31][C:30](=[O:32])[C:29]3[C:24](=[CH:25][C:26]4[CH2:33][CH2:34][CH2:35][CH2:36][C:27]=4[CH:28]=3)[N:23]=2)[CH:21]=1)=[O:16])[CH3:13]

Komponenten

3

Edukt 2

HCID 751935,6,7,8-Tetrahydro-2-naphthylamineHCID 1363371821-(1-oxo-1,2,7,8,9,10-hexahydro-benzo[f]quinazolin-3-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 1363371811-(4-oxo-3,4,6,7,8,9-hexahydro-benzo[g]quinazolin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester

Versuchsvorschrift

The titled compound was prepared in a manner analogous to Example 131, steps A-B, using 5,6,7,8-tetrahydro-naphthalen-2-ylamine in step A. Step B yielded a 2:1 mixture of the titled compound and 1-(1-oxo-1,2,7,8,9,10-hexahydro-benzo[f]quinazolin-3-yl)-1H-pyrazole-4-carboxylic acid ethyl ester.

Aufarbeitung

  1. customThe titled compound was prepared in a manner analogous to Example 131, steps A-B
  2. customStep B yielded

Quellen und Nachweise

ORD-Eintrag
ord-185c4996f7294a8cb135dc87f8f4665f
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937078B2

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