Ammonium Acetate → HCID 86688149, Verbindung

HRID 1428944Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1428944
[CH2:1]([O:8][CH2:9][C:10]([N:12]([CH2:24][CH3:25])[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=1)=O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:30]>ClCCl>[CH2:1]([O:8][CH2:9][C:10]1[N:12]([CH2:24][CH3:25])[CH:13]=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=2)[N:30]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 517165Ammonium AcetateHCID 86688147HCID 86688147, Verbindung

Produkt 1

HCID 86688149HCID 86688149, VerbindungAusbeute 74,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

5.8 g 2-benzyloxy-N-ethyl-N-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-acetamide and 4 g ammonium acetate was melted at 200° C. for 30 min Dichlormethane was added and the mixture was washed with aqueous potassiumhydrogen carbonate solution. The organic layer was evaporated. The residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1) to yield 4.1 g of the desired product. Rt: 0.74 min (method J), (M+H)+: 325

Aufarbeitung

  1. customfor 30 min
  2. additionwas added
  3. washthe mixture was washed with aqueous potassiumhydrogen carbonate solution
  4. customThe organic layer was evaporated
  5. customThe residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1)

Quellen und Nachweise

ORD-Eintrag
ord-8daea9d4e22d48eb8921d82f9d79a469
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937176B2

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