Hydrochloric Acid → (S)-Pyrrolidine-2-carboxamide monohydrochloride

HRID 1429198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1429198
[C:1]([C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1C(OC(C)(C)C)=O)(=[O:3])[NH2:2].[ClH:16].O1CCOCC1>>[ClH:16].[NH:5]1[CH2:6][CH2:7][CH2:8][C@H:4]1[C:1]([NH2:2])=[O:3]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 7019053tert-butyl (S)-2-carbamoylpyrrolidine-1-carboxylate

Produkt 1

HCID 12707183(S)-Pyrrolidine-2-carboxamide monohydrochlorideAusbeute 104 %

Versuchsvorschrift

To (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate (29.8 g, 139 mmol) was added a solution of 4 N HCl in dioxane (209 mL, 836 mmol), and the resultant mixture was stirred at room temperature for 18 hours. The mixture was then concentrated and triturated with diethyl ether then vacuum filtered and dried under vacuum to provide 21.6 g (104%) of the title product as a colorless solid.

Aufarbeitung

  1. concentrationThe mixture was then concentrated
  2. customtriturated with diethyl ether
  3. filtrationvacuum filtered
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-759b2798a8304ca88c2341c3d33ca656
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08937150B2

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