Potassium Carbonate → 4(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

HRID 1429366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1429366
FC(F)(F)C(O)=O.Br[CH2:9][C:10]1[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=1[CH2:12][O:13][CH2:14][CH:15]([NH2:24])[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[Br:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][CH:15]2[NH:24][CH2:9][C:10]3[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=3[CH2:12][O:13][CH2:14]2)=[CH:18][CH:19]=1

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 673822521((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt

Produkt 1

HCID 674173634(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocineAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of compound 3k (1.6 g, 3.9 mmol) and K2CO3 (1.6 g, 12 mmol) in dry THF (30 mL) was stirred at rt overnight. LCMS indicated the total consumption of compound 3k. The reaction mixture was filtered and the filtrate was evaporated in vacuum to give 3l as a white solid (1.1 g, 86% yield).

Aufarbeitung

  1. customthe total consumption of compound 3k
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-171454f8bf764c998f04d306ce529fd9
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940722B2

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