Ethanol → 4-Methoxyphenoxyacetic acid

HRID 1429434

Reaktionsgleichung

Reaktionsgleichung von HRID 1429434
C[C:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)[C:3]([O:5]CC)=[O:4].[OH-].[Na+].C[CH2:19][OH:20]>>[CH3:19][O:20][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:2][C:3]([OH:5])=[O:4])=[CH:15][CH:14]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 86476Deschloroclofibrate

Produkt 1

HCID 746494-Methoxyphenoxyacetic acid

Versuchsvorschrift

To a solution of ethyl 2-methyl-2-phenoxypropanoate (210 mg, 1 mmol) in EtOH (10 ml) was added 10% NaOH aqueous solution (10 mL) at 26° C. The mixture was stirred for 30 min and then concentrated before the addition of water (20 mL) and washing with ethyl acetate (2×20 mL). The aqueous layer was acidified with 2N HCL until pH 3 and extracted with ethyl acetate (2×20 ml). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound which was used in next step without further purification.

Aufarbeitung

  1. concentrationconcentrated before the addition of water (20 mL)
  2. washwashing with ethyl acetate (2×20 mL)
  3. extractionextracted with ethyl acetate (2×20 ml)
  4. washThe organic layer was washed with brine (30 mL)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-23aa1f7efd7a4f46bed9eb2918d69118
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940726B2

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