Phosphorus oxychloride → 8-(Benzyloxy)-2-chloroquinoline

HRID 1429505Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1429505
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[N:17]=[C:16](O)[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:22]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[N:17]=[C:16]([Cl:22])[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178515619HCID 178515619, Verbindung

Produkt 1

HCID 220422348-(Benzyloxy)-2-chloroquinolineAusbeute 85 %

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

8-(benzyloxy)quinolin-2-ol (6.6 g, 26.3 mmol) was dissolved in POCl3 (50 mL). The mixture was stirred at 90° C. for 16 h. The POCl3 was evaporated and to the residue was added EtOAc (100 mL) and the solution was washed with a.q. NaHCO3 (80 mL) and H2O (80 mL). The EtOAc was removed under vacuum to give the desired compound (6.0 g, yield 85%). LCMS (m/z): 270.1 [M+H]+

Aufarbeitung

  1. customThe POCl3 was evaporated and to the residue
  2. additionwas added EtOAc (100 mL)
  3. washthe solution was washed with a.q
  4. customThe EtOAc was removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9ada1b3ac81e45e98a07c479c0076117
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940726B2

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