HCID 59805850, Verbindung → HCID 23218604, Verbindung

HRID 1429660Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1429660
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:7][CH2:8][C:9](=[O:10])[CH2:14][CH2:15]1

Komponenten

3

Edukt 1

HCID 59805850HCID 59805850, Verbindung

Produkt 1

HCID 23218604HCID 23218604, VerbindungAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of D3 (7.9 g, 29.4 mmol) in hydrochloric acid (5N, 150 ml) was heated at 50° C. for 2 h. After this period, the reaction mixture was washed with diisopropyl ether (100 ml) and then a saturated solution of sodium hydrogen carbonate (100 ml). The mixture was then extracted with dichloromethane and the extracts dried (MgSO4) and the solvents evaporated in vacuo to give D4 (5.4 g, 82%). C12H13F2NO requires 225; Found 226 (MH+)

Aufarbeitung

  1. waitAfter this period
  2. washthe reaction mixture was washed with diisopropyl ether (100 ml)
  3. extractionThe mixture was then extracted with dichloromethane
  4. dry with materialthe extracts dried (MgSO4)
  5. customthe solvents evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ccfb022391a645d6a65c2d2295802ece
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940743B2

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