Methylamine → 5-fluoro-N-methyl-2-nitroaniline

HRID 1430399Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1430399
[CH3:1][NH2:2].F[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12]>CO>[F:10][C:8]1[CH:7]=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([CH:9]=1)[NH:2][CH3:1]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 679672,4-Difluoronitrobenzene

Produkt 1

HCID 229057745-fluoro-N-methyl-2-nitroanilineAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

An aqueous solution of 40% methyl amine (61 mL, 0.71 mol) was added dropwise to a methanol solution (200 mL) of 2,4-difluoronitrobenzene (46.7 g, 0.29 mol) under ice cooling, and the mixture was stirred for 1 hour under the same temperature. The reaction solution was poured into ice water. Precipitated crystals were collected by filtration, followed by washing with water. The resulting crystals were dried at 50° C., thereby obtaining 47.6 g of a yellow, powdery target compound (yield: 95%).

Aufarbeitung

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washby washing with water
  4. customThe resulting crystals were dried at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-2bd870b8d0c641ecb21d08a7c687a969
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08940889B2

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