5-Morpholinopyridin-3-amine → 7-fluoro-3-(1-methylethyl)-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine

Beteiligte Stoffe

Reaktionsschritte

Prepared according to Procedure H using 4-chloro-7-fluoro-3-isopropyl-2-(pyridin-2-yl)quinoline (45.0 mg, 0.150 mmol) and 5-morpholinopyridin-3-amine in toluene to give 7-fluoro-3-(1-methylethyl)-N-(5-(4-morpholinyl)-3-pyridinyl)-2-(2-pyridinyl)-4-quinolinamine. 1H NMR (400 MHz, chloroform-d) δ ppm 8.69-8.76 (1H, m), 7.84-7.92 (2H, m), 7.71-7.83 (3H, m), 7.68 (1H, d, J=7.8 Hz), 7.39 (1H, ddd, J=7.6, 4.9, 1.2 Hz), 7.18 (1H, ddd, J=9.2, 8.1, 2.6 Hz), 6.25 (1H, t, J=2.3 Hz), 6.03 (1H, s), 3.71-3.83 (4H, m), 3.33-3.43 (1H, m), 2.95-3.08 (4H, m), 1.32 (6H, d, J=7.2 Hz). Mass Spectrum (ESI) m/e=444.2 (M+1).

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