1,1-Dimethoxyethyl(dimethyl)amine → 1-(4-Fluorobenzyl)-5-methanesulfonyl-2-(3-methyl-[1,2,4]oxadiazol-5-yl)indole

Temperatur

110 °C

A mixture of 1-(4-fluorobenzyl)-5-methanesulfonylindole-2-carboxamide (63 mg) and dimethylacetamide dimethylacetal (1 ml) was stirred at 110° C. for 1 hour. The reaction mixture was concentrated under reduced pressure. A mixture of the resulting residue, hydroxylamine hydrochloride (25 mg), a 2N aqueous sodium hydroxide solution (0.18 ml), 1,4-dioxane (0.4 ml) and acetic, acid (0.4 ml) was stirred at 90° C. for 2 hours. Water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (hexane:ethyl acetate=1:1) to obtain 50 mg of the desired product as a white crystal.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionA mixture of the resulting residue, hydroxylamine hydrochloride (25 mg)
3. stirringa 2N aqueous sodium hydroxide solution (0.18 ml), 1,4-dioxane (0.4 ml) and acetic, acid (0.4 ml) was stirred at 90° C. for 2 hours
4. additionWater was added
5. extractionthe mixture was extracted with ethyl acetate
6. washThe organic layer was washed with water
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated under reduced pressure

ORD-Eintrag

ord-0dfbf076857c498d9d030cb27cec8a4d

Quelldatensatz

uspto-grants-2009_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07612070B2